کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5032703 | 1471130 | 2017 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dynamic mechanical analysis to assess viscoelasticity of liver tissue in a rat model of nonalcoholic fatty liver disease
ترجمه فارسی عنوان
تجزیه و تحلیل مکانیکی پویا برای ارزیابی ویزو کلاسیکیت بافت کبدی در یک مدل موش مبتلا به بیماری کبد چرب غیرالکلی
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کلمات کلیدی
Ultrasound elastography - الاستوگرافی سونوگرافیNonalcoholic fatty liver disease - بیماری کبدی چربی غیر الکلیDynamic mechanical analysis - تجزیه و تحلیل مکانیکی پویاSteatosis - تغییر چرب یا استئاتوز Rheological property - خاصیت رئولوژیکیloss modulus - مدول از دست دادنStorage modulus - مدول ذخیره سازیViscoelasticity - ویسکوالاستیسیته
موضوعات مرتبط
مهندسی و علوم پایه
سایر رشته های مهندسی
مهندسی پزشکی
چکیده انگلیسی
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder in both developed and developing countries. A noninvasive method of detecting early stage NAFLD and distinguishing non-alcoholic steatohepatitis (NASH) from simple steatosis (SS) would be useful. The over-accumulation of fat in hepatocytes alters the physical microstructure and chemical contents of the liver tissue. This study included dynamic mechanical analysis (DMA) testing on liver samples from a rat model of NAFLD to determine whether the tissue shows any significant changes in viscoelasticity due to the histological changes. Liver steatosis was induced in 57 rats by gavage feeding of a high fat emulsion; 12 rats received a standard diet only and served as controls. Each rat provided 2 or 3 samples for DMA tests. The shear modulus and loss modulus were measured at 9 frequency points evenly-spaced in the range from 1Â Hz to 41Â Hz. The phase velocity of shear wave was calculated from the measured modulus. Multivariate T2 test was used to assess the significance of intra-group difference. The results showed significant changes (pâ<â0.05) in storage modulus in livers with moderate to severe (S2 to S4) steatosis in comparison with livers without steatosis (S0), while the loss modulus demonstrated significant changes earlier in stage S1, indicating that fat accumulation affects the mechanical properties of liver, particularly viscosity. However, no significant differences were observed between the steatosis grades. These results also suggest that mild inflammation may affect the mechanical properties, which requires further verification. These findings provide new information about the mechanical properties of livers with NAFLD in low frequency range and suggest that it is possible to distinguish normal livers from livers with NAFLD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Engineering & Physics - Volume 44, June 2017, Pages 79-86
Journal: Medical Engineering & Physics - Volume 44, June 2017, Pages 79-86
نویسندگان
Zhang Xinyu, Gao Xuehua, Zhang Pengpeng, Guo Yanrong, Lin Haoming, Diao Xianfen, Liu Yingxia, Dong Changfeng, Hu Yaxin, Chen Siping, Chen Xin,