Mucosal transfer of wheat germ agglutinin modified lipid-polymer hybrid nanoparticles for oral delivery of oridonin

The fate of wheat germ agglutinin-modified lipid-polymer hybrid nanoparticles (WGA-LPNs) in mucus can be described as follows: upon WGA-LPNs exposure to the mucus layer, WGA-LPNs interact with mucin. Despite the interaction with mucin hindering movement, WGA-LPNs penetrate the mucus layer and are taken up by enterocytes. Oridonin-loaded WGA-LPNs exhibited improved bioavailability with desirable pharmacokinetics and effective antitumor activity in HepG2 tumor-bearing nude mice.292