کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5033074 | 1370006 | 2017 | 10 صفحه PDF | دانلود رایگان |
Neuroblastoma (NB) is one of the most commonly seen malignancies in childhood and infancy. Cantharidin is a highly potent natural toxin that possesses potent anti-tumor properties on various cancers including NB. However, exposure to cantharidin can cause severe chemical burns and application of cantharidin for cancer therapy is limited. Here we report a strategy of bundling cantharidin within a hybrid platinum (IV) prodrug conjugate. This hydrophobic drug conjugate, ie, CanPt can be further formulated into liposome for drug delivery to minimize the exposure of cantharidin to normal cells for efficient chemotherapeutic agent against NB.
Graphical AbstractA hybrid hydrophobic platinum (IV) prodrug CanPt made from picoplatin and cantharidin was used for liposome drug delivery.124
Journal: Nanomedicine: Nanotechnology, Biology and Medicine - Volume 13, Issue 1, January 2017, Pages 287-296