کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5040575 1473902 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Studying brain-regulation of immunity with optogenetics and chemogenetics; A new experimental platform
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
پیش نمایش صفحه اول مقاله
Studying brain-regulation of immunity with optogenetics and chemogenetics; A new experimental platform
چکیده انگلیسی


- As tools emerge to identify putative targets in the brain, we are presented with the opportunity to systematically analyze their functional contribution to immune regulation.
- An experimental platform that combines targeted manipulations of the brain, immune analysis and dissection of the relay systems from the brain to the immune system is proposed.
- Optogenetics and chemogenetics enable establishing causality between brain activity and changes in the immune system.

The interactions between the brain and the immune system are bidirectional. Nevertheless, we have far greater understanding of how the immune system affects the brain than how the brain affects immunity. New technological developments such as optogenetics and chemogenetics (using DREADDs; Designer Receptors Exclusively Activated by Designer Drugs) can bridge this gap in our understanding, as they enable an unprecedented mechanistic and systemic analysis of the communication between the brain and the immune system. In this review, we discuss new experimental approaches for revealing neuronal circuits that can participate in regulation of immunity. In addition, we discuss methods, specifically optogenetics and chemogenetics, that enable targeted neuronal manipulation to reveal how different brain regions affect immunity. We describe how these techniques can be used as an experimental platform to address fundamental questions in psychoneuroimmunology and to understand how neuronal circuits associate with different psychological states can affect physiology.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 65, October 2017, Pages 1-8
نویسندگان
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