کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5040598 1473902 2017 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Maternal care modulates the febrile response to lipopolysaccharide through differences in glucocorticoid receptor sensitivity in the rat
ترجمه فارسی عنوان
مراقبت از مادر باعث پاسخ دادن تب به لیپوپلی ساکارید می شود از طریق تفاوت های حساسیت گیرنده گلوکوکورتیکوئیدی در موش صحرایی
موضوعات مرتبط
علوم زیستی و بیوفناوری ایمنی شناسی و میکروب شناسی ایمونولوژی
چکیده انگلیسی


- Low maternal care heightens febrile response to lipopolysaccharide challenge in rats.
- Low maternal care increases corticosterone and spleen glucocorticoid receptors.
- Low maternal care reduces plasma IL-6 and increases central IL-6 expression.
- RU-486 eliminates differences in LPS fever based on early life maternal care.
- Differential sensitivity to RU-486-LPS challenge based on early maternal care.

Early life adversity increases the risk for later infection. The febrile response is a potent mechanism to combat infection. We found that variations in maternal care influence the febrile response to 50 µg/kg lipopolysaccharide (LPS) challenge in adult male rats. Offspring from low-licking/grooming (LG) mothers had an increased febrile response compared to offspring from high-LG mothers challenged with LPS. Low-LG offspring had reduced plasma IL-6 at one and two hours post challenge compared to high-LG offspring. IL-6 gene expression in the anterior hypothalamus was induced following LPS challenge in low-LG offspring but not in high-LG offspring at two hours post challenge. Occupancy of the transcription factor nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) to the IL-6 promoter region in the anterior hypothalamus was greater in low-LG offspring treated with LPS than in high-LG offspring. These findings suggest greater activation of thermoregulatory neurons in the anterior hypothalamus of low-LG compared to high-LG offspring following LPS challenge. Low-LG offspring had greater plasma corticosterone levels following LPS challenge and they had enhanced glucocorticoid receptors (GR) in the spleen compared to high-LG offspring. Enhanced glucocorticoids and glucocorticoid receptor sensitivity associated with reduced IL-6 induction early post challenge in low-LG offspring. Challenge with RU-486 prior to LPS challenge eliminated differences in the febrile response between offspring of high and low-LG mothers. Individual differences in GR sensitivity may modulate differences in the febrile response to LPS challenge, exerting a long-term influence on the capacity to recover from infection.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Brain, Behavior, and Immunity - Volume 65, October 2017, Pages 239-250
نویسندگان
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