کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5043084 1475128 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Amnestic drugs in the odor span task: Effects of flunitrazepam, zolpidem and scopolamine
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
پیش نمایش صفحه اول مقاله
Amnestic drugs in the odor span task: Effects of flunitrazepam, zolpidem and scopolamine
چکیده انگلیسی


- The odor span task (OST) assesses rodent's ability to remember multiple odor stimuli.
- Positive GABAA modulator flunitrazepam selectively impaired OST accuracy.
- However, flunitrazepam effects did not depend on the number of items to remember.
- Alpha-1 selective positive GABAA modulator zolpidem did not selectively impair OST accuracy.
- Cholinergic antagonist scopolamine did not selectively impair OST accuracy.

The odor span task is an incrementing non-matching-to-sample procedure designed to provide an analysis of working memory capacity in rodents. The procedure takes place in an arena apparatus and rats are exposed to a series of odor stimuli in the form of scented lids with the selection of new stimuli reinforced. This procedure makes it possible to study drug effects as a function of the number of stimuli to remember. In the present study, the non-selective positive allosteric GABAA receptor modulator flunitrazepam impaired odor span performance at doses that did not affect a control odor discrimination. In contrast, the alpha-1 selective positive GABAA receptor modulator zolpidem and the cholinergic receptor antagonist scopolamine only impaired odor span at doses that produced more global impairment, including decreased accuracy in the control discrimination and increased response omissions in the both the odor span and control discrimination procedures. Even though the effects of flunitrazepam were selective to odor span performance, they did not depend on the number of stimuli to remember-the same degree of impairment occurred regardless of the memory load. These findings suggest that flunitrazepam interfered selectively with conditional discrimination performance rather than working memory and tentatively suggest that flunitrazepam's selective effects in the odor span task relative to the control odor discrimination are mediated by one or more non-alpha1 GABAA receptor subtypes.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Learning and Memory - Volume 145, November 2017, Pages 67-74
نویسندگان
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