کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5045881 1475896 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Two-year prognosis after acute coronary syndrome in younger patients: Association with feeling depressed in the prior year, and BDI-II score and Endothelin-1
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
Two-year prognosis after acute coronary syndrome in younger patients: Association with feeling depressed in the prior year, and BDI-II score and Endothelin-1
چکیده انگلیسی


- Depression is associated with adverse post-acute coronary syndrome (ACS) prognosis.
- Endothelin (ET)-1 has been previously linked to adverse post-ACS outcomes.
- We examined the effects of feeling depressed in the previous year, the BDI-II score and ET-1 levels on 2-year prognosis in younger ACS patients.
- Neither the BDI-II score, nor ET-1 predicted prognosis.
- Feeling depressed in the year preceding hospitalization for ACS predicted prognosis.

ObjectiveTo examine the effects of depressive symptoms and Endothelin (ET)-1 on 2-year prognosis in younger patients with acute coronary syndrome (ACS). Depression is associated with poor post-ACS prognosis; however, few investigations have focused on younger patients. Importantly, the studies that did emphasize younger patients suggested that the influence of depression on prognosis could be more robust in younger subgroups. The particular links between depression and poor prognosis in younger patients have yet to be definitively determined. ET-1 is a potent endogenous vasoconstrictor that has been previously linked to adverse post-ACS outcomes.MethodsThe sample (n = 153) included male (age ≤ 50 years) and female (age ≤ 55 years) ACS patients. Blood samples for ET-1 assessment were collected within 2-3 h of ACS hospital admission. Depressive symptoms were assessed with the Beck Depression Inventory (BDI) II within 2-5 days of admission. The primary outcome was defined as a composite of major adverse cardiovascular events (MACE), including recurrent myocardial infarction, emergent coronary revascularization, and all-cause mortality within 2 years after index admission.ResultsDuring the follow-up period, 23 patients experienced MACE. Neither the BDI-II score nor ET-1 predicted MACE in unadjusted analyses or in analyses adjusted for demographic characteristics, comorbidities and troponin levels. In the supplementary analyses, feeling depressed in the year preceding ACS predicted MACE.ConclusionsIn this cohort of younger ACS patients, feeling depressed in the year preceding ACS admission predicted MACE in the 2 years after baseline ACS event, while neither the BDI-II score, nor circulating ET-1 level predicted this outcome.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Psychosomatic Research - Volume 99, August 2017, Pages 8-12
نویسندگان
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