کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5112 341 2016 6 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
MicroRNA expression prediction: Regression from regulatory elements
ترجمه فارسی عنوان
پیش بینی بیان MicroRNA: رگرسیون از عناصر نظارتی
کلمات کلیدی
ریز RNA؛ ریزآرایه؛ بیان ژن
MicroRNA; Microarray; Gene expression
موضوعات مرتبط
مهندسی و علوم پایه مهندسی شیمی بیو مهندسی (مهندسی زیستی)
چکیده انگلیسی

MicroRNAs are known as important actors in post-transcriptional regulation and relevant biological processes. Their expression levels do not only provide information about their own activities but also implicitly explain the behaviors of their targets, thus, in turn, the circuitry of underlying gene regulatory network. In this study, we consider the problem of estimating the expression of a newly discovered microRNA with known promoter sequence in a certain condition where the expression values of some known microRNAs are available. To this end, we offer a regression model to be learnt from the expression levels of other microRNAs obtained through a microarray experiment. To our knowledge, this is the first study that evaluates the predictability of microRNA expression from the regulatory elements found in its promoter sequence. The results obtained through the experiments on real microarray data justify the applicability of the framework in practice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biocybernetics and Biomedical Engineering - Volume 36, Issue 1, 2016, Pages 89–94
نویسندگان
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