کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5119549 1485964 2017 5 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
THC inhibits the expression of ethanol-induced locomotor sensitization in mice
ترجمه فارسی عنوان
THC مانع بیان حساسیت حرکتی ناشی از اتانول در موش ها می شود
کلمات کلیدی
الکل؛ شاهدانه؛ حساسیت؛ وابستگی؛ سیستم اندو کانابینوئید؛ رفتار
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


- THC, the main compound in cannabis, interferes in an ethanol-related behavior.
- THC inhibits the expression of locomotor sensitization induced by ethanol.
- Activation of the endocannabinoid system may be important in ethanol therapies.

The motivational circuit activated by ethanol leads to behavioral changes that recruit the endocannabinoid system (ECS). Case reports and observational studies suggest that the use of Cannabis sp. mitigates problematic ethanol consumption in humans. Here, we verified the effects of the two main phytocannabinoid compounds of Cannabis sp., cannabidiol (CBD) and delta-9-tetrahydrocannabinol (THC), in the expression of ethanol-induced locomotor sensitization in mice. Male adult DBA/2 mice were exposed to locomotor sensitization by daily intraperitoneal injections of ethanol (2.5 g/kg) for 12 days; control groups received saline. After the acquisition phase, animals were treated with cannabinoids: CBD (2.5 mg/kg); THC (2.5 mg/kg); CBD + THC (1:1 ratio), or vehicle for 4 days with no access to ethanol during this period. One day after the last cannabinoid injection, all animals were challenged with ethanol (2.0 g/kg) to evaluate the expression of the locomotor sensitization. Mice treated with THC alone or THC + CBD showed reduced expression of locomotor sensitization, compared to the vehicle control group. No effects were observed with CBD treatment alone. Our findings showing that phytocannabinoid treatment prevents the expression of behavioral sensitization in mice provide insight into the potential therapeutic use of phytocannabinoids in alcohol-related problems.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Alcohol - Volume 65, December 2017, Pages 31-35
نویسندگان
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