کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5119843 1486111 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Discriminative stimulus and locomotor effects of para-substituted and benzofuran analogs of amphetamine
ترجمه فارسی عنوان
محرک های تشخیصی و اثرات حرکتی پارا زدوده و آنزیم های بنفوروان آمفتامین
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علم عصب شناسی علوم اعصاب رفتاری
چکیده انگلیسی


- Benzofuran and substituted amphetamines are increasingly found in “Ecstasy”.
- 5-(2-Aminopropyl)-benzofuran (5-APB) and 6-(2-aminopropryl)-2,3-dihydrobenzofuran (6-APDB) were primarily 3,4-methylenedioxymethamphetamine (MDMA)-like.
- 4-Fluoroamphetamine (4-FA) was similar to cocaine, methamphetamine, and MDMA, but not 2,5-dimethoxy-4-methylamphetamine (DOM).
- 4-FA may be more likely to engender compulsive use than the benzofurans.

Novel psychoactive substances have maintained a prominent role in the global drug culture, despite increased regulation by governing bodies. Novel compounds continue to become available on the market, often in “Ecstasy” or “Molly” formulations in lieu of MDMA, at a much faster rate than they can be properly characterized. The current study aimed to investigate the discriminative stimulus and locomotor effects of three putatively entactogenic compounds that have become increasingly prevalent on the drug market: 5-(2-aminopropyl)-benzofuran (5-APB), 6-(2-aminopropryl)-2,3-dihydrobenzofuran (6-APDB), and 4-fluoroamphetamine (4-FA). Locomotor stimulant effects were assessed in an open-field assay for locomotor activity using Swiss-Webster mice. Discriminative stimulus effects were assessed in Sprague-Dawley rats trained to discriminate either cocaine, methamphetamine, DOM, or MDMA from vehicle. The benzofuran compounds produced locomotor stimulation whereas 4-FA depressed locomotor activity. The benzofurans substituted for the discriminative stimulus effects of MDMA, but only partially or not at all for methamphetamine, cocaine, and DOM, whereas 4-FA fully substituted for MDMA, methamphetamine and cocaine, but not DOM. These results indicate an MDMA-like pattern of abuse might be expected for the benzofurans, whereas 4-FA may be substituted for psychostimulants and MDMA.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Drug and Alcohol Dependence - Volume 180, 1 November 2017, Pages 39-45
نویسندگان
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