Morning administration of oral methamphetamine dose-dependently disrupts nighttime sleep in recreational stimulant users

- Methamphetamine (MA) use is associated with acute sleep disruptions.
- We administered 0, 20, and 40 mg MA to recreational stimulant users at 815AM.
- MA disrupted sleep continuity and architecture from 10:20P.M. to 06:15A.M.
- Effects of MA on sleep were robust and showed clear dose-dependence.
- Research on MA effects on sleep in naturalistic settings is warranted.

IntroductionUse of amphetamine-type stimulants (e.g., methamphetamine) is associated with acute sleep disruptions. No prior reports have characterized the acute effects of methamphetamine on sleep using polysomnography, the gold standard for objective sleep monitoring.MethodsRecreational stimulant users (n = 19) completed a baseline assessment, which included questionnaires assessing demographic and substance use characteristics, and the Pittsburgh Sleep Quality Index (PSQI), which assesses sleep quality over the past month. Participants were administered 0 mg (placebo), 20 mg, or 40 mg oral methamphetamine at 08:15 h on study days, using a double-blind, randomized, within-subjects design. Sleep was monitored using polysomnography from 22:20 that evening until 06:15 the following morning.ResultsPSQI scores indicated more than half of participants reported poor sleep quality at baseline. Methamphetamine dose-dependently increased sleep latency, and decreased total sleep time, sleep efficiency, time in NREM 2 sleep, number of REM periods, and total time in REM sleep. Sleep under placebo conditions was consistent with what would be expected from healthy adults.ConclusionsMorning oral administration of methamphetamine produces robust disruptions in nighttime sleep. Future research should examine relations between stimulant use and sleep disruption in naturalistic settings, with regard to both stimulant abuse and licit prescription use.