کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5123048 1487200 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Iodine status and thyroid nodules in females: a comparison of Cyprus and Romania
ترجمه فارسی عنوان
وضعیت ید و ندولهای تیروئید در زنان: مقایسه قبرس و رومانی
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های عفونی
چکیده انگلیسی


- Mild iodine deficiency in Cyprus, but not in Romania.
- Albeit non-significant, increased thyroid nodular risk for those with inadequate iodine.
- Need for iodine monitoring programme in Cyprus.

ObjectivesThe increased comparative prevalence rates of thyroid cancer in Cyprus (>EU average) led us to conduct this study on possible risk factors of thyroid nodules. Romania served as a reference with a comparative thyroid cancer prevalence < EU average. This study aimed to assess the association between urinary iodine (UI) and thyroid nodules in adult females (n = 208) from Cyprus and Romania.Study designA case-control study (n = 208).MethodsCases were females with ultrasound-confirmed thyroid nodules and controls with confirmed absence of nodules. In both countries, subjects underwent ultrasound medical examinations, completed a questionnaire and offered a spot urine sample.ResultsMedian UI level in Cyprus was 94 μg/L, whereas 32% of the Cypriot UI was < 50 μg/L, classifying the population as mildly iodine deficient. In Romania, both cases and controls were iodine sufficient. No significant differences (P > 0.05) in serum free thyroxin (fT4) and thyroid stimulating hormone (TSH) levels were found between cases and controls. Cases had lower median TSH levels compared with controls (1.4 mIU/L and 1.7 mIU/L, P = 0.060), but serum TSH and free thyroxin levels were within normal range. Albeit non-significant, participants with inadequate UI (<100 μg/L) had increased risk for thyroid nodules (odds ratio = 1.40, 95% confidence interval = 0.70, 2.81, P = 0.346), using multiple logistic regression after adjusting for age, body mass index, education, country and serum TSH.ConclusionsThis was the first study to quantify UI levels in Cyprus. While the Romanian iodine fortification programme reflected onto its UI levels, a representative assessment of iodine status in Cyprus will address the necessity of an iodine fortification programme.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Public Health - Volume 143, February 2017, Pages 37-43
نویسندگان
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