کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5124312 1378442 2017 4 صفحه PDF ندارد دانلود رایگان
عنوان انگلیسی مقاله
Botulinum Toxin Dosing Trends in Spasmodic Dysphonia Over a 20-year Period
کلمات کلیدی
Spasmodic dysphonia; Botulinum toxin; Dosing intervals; Initial dose; Trend;
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Botulinum Toxin Dosing Trends in Spasmodic Dysphonia Over a 20-year Period
چکیده انگلیسی

SummaryObjectivesThe study aims to (1) identify the botulinum toxin (BTX) dosing trend in a cohort of patients who received at least 20 injections for the treatment of adductor spasmodic dysphonia (ADSD), (2) describe two distinct BTX dosing trends in treating ADSD (a “classic” dosing trend that initially decreases before stabilizing, and a “fluctuating” dosing trend), and (3) determine if patients with the “classic” dosing trend differed in age or in dosing intervals from those with the “fluctuating” dosing trend.Study designThis is a retrospective case series.MethodsOf 149 patients who received a total of 2484 BTX injections for the treatment of spasmodic dysphonia in 1993–2013, 49 patients received at least 20 injections. The BTX dose and the interval between doses were recorded. The mean dose of injections 1–20 was determined. The age at initial injection, initial dose, and interval in days between treatments were compared for the “fluctuating” and “classic” groups.ResultsThe cohort exhibits a significant decrease in dose during the first 10–15 injections. The “fluctuating” group had a significantly shorter interval between injections (mean interval = 97.09 days, SD = 29.41; mean interval = 136.90 days, SD = 43.76, P = 0.002). The mean age at initial dose was not significantly different between the “classic” and “fluctuating” groups.ConclusionsThe average BTX dose of patients with ADSD who receive long-term injections significantly decreases during the initial 10–15 injections before stabilizing. Patients who exhibit the “fluctuating” dosing pattern have a significantly shorter interval between injections than those with the “classic” dosing pattern.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Voice - Volume 31, Issue 1, January 2017, Pages 107-110
نویسندگان
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