کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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5130650 | 1490849 | 2017 | 7 صفحه PDF | دانلود رایگان |
- A low-cost microdroplet chip was fabricated using paper cover and electrochemiluminescent array.
- Vertically aligned silica nanochannel was modified as a signal amplification strategy.
- Simultaneous analysis of six samples can be accomplished in 1 min.
This paper describes a simple and miniaturized microdroplet chip (μchip) that is constructed with a silica nanochannel (SNC)-assisted electrode array and a hydrophobic paper cover (SNC&P-μchip). Vertically aligned SNCs with uniform pore size of 2-3 nm in diameter and negatively charged surface can significantly accelerate the mass transport of the positively charged tris(2,2'-bipyridyl) ruthenium (II), resulting in a remarkably enhanced electrochemiluminescence (ECL) signal. The SNC-assisted electrode array was coupled to a low cost paper cover to achieve simultaneous detection of six samples in 1 min. The feasibility and universality of the SNC&P-μchip was evaluated by detecting a series of alkaloidal drugs both in buffers and in human serum. The performance of the SNC&P-μchip was fully validated with respect to linearity (0.9999 > R > 0.9939), sensitivity (limits of detection from 1.799 nM to 11.43 nM), and accuracy (recovery rate between 94.38% and 109.12%). The facile and economic SNC&P-μchip shows promising potential for rapid drug detection in complex biofluids.
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Journal: Analytica Chimica Acta - Volume 983, 29 August 2017, Pages 96-102