Designed graphene-peptide nanocomposites for biosensor applications: A review

- A comprehensive review on the fabrication and application of graphene-peptide nanocomposites was presented.
- The design of peptide sequences for biofunctionalization of various graphene materials was presented.
- Multi-strategies on the fabrication of biosensors with graphene-peptide nanocomposites were discussed.
- Designed graphene-peptide nanocomposites showed wide biosensor applications.

The modification of graphene with biomacromolecules like DNA, protein, peptide, and others extends the potential applications of graphene materials in various fields. The bound biomacromolecules could improve the biocompatibility and bio-recognition ability of graphene-based nanocomposites, therefore could greatly enhance their biosensing performances on both selectivity and sensitivity. In this review, we presented a comprehensive introduction and discussion on recent advance in the synthesis and biosensor applications of graphene-peptide nanocomposites. The biofunctionalization of graphene with specifically designed peptides, and the synthesis strategies of graphene-peptide (monomer, nanofibrils, and nanotubes) nanocomposites were demonstrated. On the other hand, the fabrication of graphene-peptide nanocomposite based biosensor architectures for electrochemical, fluorescent, electronic, and spectroscopic biosensing were further presented. This review includes nearly all the studies on the fabrication and applications of graphene-peptide based biosensors recently, which will promote the future developments of graphene-based biosensors in biomedical detection and environmental analysis.

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