کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5131532 1378755 2017 4 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
An optical alignment system improves precision of soluble aggregate quantitation by sedimentation velocity analytical ultracentrifugation
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
An optical alignment system improves precision of soluble aggregate quantitation by sedimentation velocity analytical ultracentrifugation
چکیده انگلیسی

Appropriate characterization of soluble aggregates is an important aspect of biologics development and manufacturing, and sedimentation velocity analytical ultracentrifugation (SV-AUC) is often used an orthogonal technique to size-exclusion chromatography (SEC) for this purpose. Precise quantification of low levels of soluble aggregates by SV-AUC can be adversely impacted by improper cell alignment. This report describes the development of an optical system capable of quantifying cell alignment that affords a substantial improvement compared to historical approaches.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Analytical Biochemistry - Volume 531, 15 August 2017, Pages 16-19
نویسندگان
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