کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5133260 1492062 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A simple and rapid method of isolation of active polypeptide complex, yolkin, from chicken egg yolk
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
A simple and rapid method of isolation of active polypeptide complex, yolkin, from chicken egg yolk
چکیده انگلیسی


- A simple and rapid method of yolkin isolation.
- Yolkin stimulates blood cells to release cytokines: IL-6; IL-10 and neurotrophin BDNF.
- A new method of yolkin isolation preserves biological activity.

A large number of bioactive peptides isolated from natural sources are known to play important physiological roles in the human body. It is possible to use these as alternative therapy agents. One example is yolkin which can be useful as a food supplement, a natural therapeutic agent for preventing and treating cognitive disorders of various origins, preferably in patients with unsatisfactory responses to known therapies. A new simple method of isolation of yolkin based on precipitation with ethanol or acetone was developed. The best precipitation efficiency of both ethanol and acetone was achieved when stirred into the starting material to a final concentration of 70%. These methods preserved the ability of yolkin to stimulate human whole blood cells to release anti-inflammatory cytokines and neurotrophins. At first we indicated that yolkin displayed a potential neuroprotective effect by the ability to stimulate cells to produce pro-survival brain derived neurotrophic factor (BDNF).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Food Chemistry - Volume 230, 1 September 2017, Pages 705-711
نویسندگان
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