کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5135555 1493429 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
In-situ functionalized monolithic polysiloxane-polymethacrylate composite materials from polythiol-ene double click reaction in capillary column format for enantioselective nano-high-performance liquid chromatography
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
In-situ functionalized monolithic polysiloxane-polymethacrylate composite materials from polythiol-ene double click reaction in capillary column format for enantioselective nano-high-performance liquid chromatography
چکیده انگلیسی


- Novel one step in-situ functionalized monolithic polysiloxane-polymethacrylate composite material.
- Functionalization and crosslinking by double thiol-ene click-type polymerization reaction.
- Poly(3-mercaptopropyl)methylsiloxane as thiol component quantitatively incorporated.
- In-situ functionalization with O-tert-butylcarbamoylquinine.
- Nano-HPLC enantiomer separation of N-3,5-dinitrobenzoylleucine on chiral monolithic capillary column.

This work reports on the proof-of-principle of preparation of novel one step in-situ functionalized monolithic polysiloxane-polymethacrylate composite materials in capillary columns for enantioselective nano-HPLC using a thiol-ene click reaction. Quinine carbamate as functional monomer and ethylene dimethacrylate as crosslinker were both used as ene components in a thermally initiated double click-type polymerization reaction with poly(3-mercaptopropyl)methylsiloxane as thiol component in presence of 1-propanol as porogenic solvent. Elemental analysis and on-capillary fluorescence measurement proved the successful incorporation of the functional chiral monomer into the polymer. Scanning electron microscopy images revealed a macroporous polymer morphology which is typical for a nucleation and growth mechanism of pore formation. The individual microglobules appear relatively spherical and smooth indicating a non-porous nature. Nano-HPLC experiments of the chiral monolithic capillary column provided successful enantiomer separation of N-3,5-dinitrobenzoylleucine as test compound in polar organic elution mode clearly documenting the successful implementation of the proposed concept towards new functionalized monolithic composite materials.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1497, 12 May 2017, Pages 172-179
نویسندگان
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