کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5137072 1494528 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A safer hypoglycemic agent for type 2 diabetes—Berberine organic acid salt
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
A safer hypoglycemic agent for type 2 diabetes—Berberine organic acid salt
چکیده انگلیسی


• Berberine organic acid salts (BOAs) were prepared with safe and edible organic acids.
• BOAs have a good hypoglycemic effect on type 2 diabetes rats.
• BOAs are superior with regard to safety from hyperchloraemia in type 2 diabetes rats.

Type 2 diabetes (T2D) often leads to metabolic disorders. Hyperchloraemia, a common electrolyte metabolic disorder and caused by excessive intake of chloride-containing acidic agents. Thus, while berberine hydrochloride (BH) elicits a good hypoglycaemic effect, its nearly 10% chloride ion component is a potential hazard for T2D patients. In this study, we prepared four berberine organic acid salts (BOAs), including berberine citrate, berberine malate, berberine succinate, and berberine fumarate. T2D rats were administered BH or BOAs (500 mg/kg d) for 6 weeks. The body weights and levels of total cholesterol, triglycerides, fasting blood glucose, fasting insulin, and insulin resistance index in administered rats were normal. Levels of Na+, K+, Cl−, HCO3−, pH, pCO2 and‘base excess (BE) in BH group showed significant differences compared with normal rats. These results suggest that BOAs are comparable to BH in terms of hypoglycaemic effects, but superior with regard to safety from hyperchloraemia in T2D rats.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 38, Part A, November 2017, Pages 399–408