کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137167 | 1494534 | 2017 | 8 صفحه PDF | دانلود رایگان |
- Anthocyanins reduce platelet aggregation in obese/overweight population.
- Anthocyanins alleviate platelet activation-dependant surface marker expression.
- Anthocyanins modulate mechanisms involved in thrombogenesis.
- Anthocyanins displays potential as a complementary antiplatelet therapeutic.
The aim was to evaluate the effect of anthocyanin (ACN) supplementation in reducing thrombogenesis and maintaining hemostasis in pro-thrombotic overweight and obese individuals. Twenty-six (MÂ =Â 9, FÂ =Â 17) overweight/obese (BMIÂ >Â 25) individuals participated in this randomized, double-blind, placebo-controlled, crossover design dietary intervention trial. Volunteers consumed ACN (320Â mg/day) or placebo capsules for 28-days followed by a two-week wash-out period. ACN supplementation inhibited adenosine diphosphate (ADP)-induced platelet activation-related conformational change and degranulation by reducing PAC-1 expression by 12% and P-selectin expression by 9% respectively. ACN supplementation also alleviated thrombogenic progression by reducing monocyte-platelet aggregate formation by 29% and platelet endothelial cell adhesion molecule-1 (PECAM-1) expression by 21%. Platelet aggregation induced by ADP, collagen and arachidonic acid was reduced by 36%, 17%, and 24% respectively. ACN supplementation has the potential to reduce the risk of thrombosis in overweight/obese population by targeting specific pathways of platelet activation/aggregation and endothelial dysfunction associated leucocyte migration.
Journal: Journal of Functional Foods - Volume 32, May 2017, Pages 131-138