کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5137508 | 1494538 | 2017 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
α-Glucosidase inhibitory activity and structural characterization of polysaccharide fraction from Rhynchosia minima root
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
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چکیده انگلیسی
Rhynchosia minima root, a renowned traditional Chinese medicinal herb, has been shown to exhibit multiple therapeutic activities. In this study, the α-glucosidase inhibitory activity of R. minima root polysaccharide fractions (PRM1, PRM3 and PRM5) is evaluated. PRM3 displays an excellent inhibitory activity with an IC50 value of 8.85 mg/mL, which is similar to that of acarbose, a positive control compound that has been applied for the control of postprandial hyperglycemia. PRM3 is a homogeneous fraction with an average molecular weight of 97.3 kDa. The results of methylation analysis, periodate oxidation and nuclear magnetic resonance (NMR) spectra reveal that the repeating units of PRM3 are mainly composed of (1 â 3,4)-α-Arap, (1 â 4,6)-β-Galp, (1 â 2,4)-β-Rhap, (1 â 3,4)-β-GalpA, T-α-Araf and T-α-Galp residues. Moreover, triple helix stereo-configuration has been proven to exist in PRM3. In summary, the strong α-glucosidase inhibitory activity and unique structural feature of PRM3 suggest that it could have a potential application in functional foods.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Functional Foods - Volume 28, January 2017, Pages 76-82
Journal: Journal of Functional Foods - Volume 28, January 2017, Pages 76-82
نویسندگان
Xuejing Jia, Jie Hu, Muxue He, Qingwen Zhang, Peng Li, Jianbo Wan, Chengwei He,