Estimation of ibuprofen and famotidine in tablets by second order derivative spectrophotometery method

A simple and accurate method for the analysis of ibuprofen (IBU) and famotidine (FAM) in their combined dosage form was developed using second order derivative spectrophotometery. IBU and FAM were quantified using second derivative responses at 272.8 nm and 290 nm in the spectra of their solutions in methanol. The calibration curves were linear in the concentration range of 100-600 μg/mL for IBU and 5-25 μg/mL for FAM. The method was validated and found to be accurate and precise. Developed method was successfully applied for the estimation of IBU and FAM in their combined dosage form.