Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency

Macrocyclic inhibitors of Factor XIa: Discovery of alkyl-substituted macrocyclic amide linkers with improved potency

Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Bioorganic & Medicinal Chemistry Letters - Volume 27, Issue 16, 15 August 2017, Pages 3833-3839

James R. Corte, Wu Yang, Tianan Fang, Yufeng Wang, Honey Osuna, Amy Lai, William R. Ewing, Karen A. Rossi, Joseph E. Jr., Steven Sheriff, Zhen Lou, Joanna J. Zheng, Timothy W. Harper, Jeffrey M. Bozarth, Yiming Wu, Joseph M. Luettgen,