کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5157808 1500601 2017 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Development of in vitro resistance to chitosan is related to changes in cell envelope structure of Staphylococcus aureus
ترجمه فارسی عنوان
توسعه مقاومت در برابر ویروس کیتوزان به تغییرات ساختار پاکت های سلولی استافیلوکوک اورئوس
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
چکیده انگلیسی
Following a serial passage experiment, a stable chitosan-resistant variant (CRV) was identified, exhibiting >50-fold reduction in its sensitivity towards chitosan. Our analyses of the CRV identified phenotypic and genotypic features that readily distinguished it from its chitosan-susceptible parental strain, including: (i) a lower overall negative cell surface charge; (ii) cross-resistance to a number of antimicrobial agents; (iii) major alterations in cell envelope structure, cellular bioenergetics and metabolism (based on transcriptional profiling); and (iv) a repaired sensor histidine kinase GraS. Our data therefore suggest a close nexus between changes in cell envelope properties with the in vitro chitosan-resistant phenotype in S. aureus SG511-Berlin.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 157, 10 February 2017, Pages 146-155
نویسندگان
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