Oleanane-type triterpene saponins with collagen synthesis-promoting activity from the flowers of Bellis perennis

Seven oleanane-type triterpene saponins, perennisosides XIII-XIX were isolated from Bellis perennis flowers. Among the saponin constituents, perennisosides XVIII, I, II, VII, IX, and XI, asterbatanoside D, bernardioside B2, and bellissaponins BS5 and BS9, significantly promoted collagen synthesis at 3-30 μM without cytotoxicity.147