Syntheses of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives as novel anticancer nucleoside analogs

A novel class of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives has been synthesized in order to identify anticancer nucleoside analogs. Several synthetic routes were devised and implemented which relied upon either SN2 displacement or reductive amination to provide the desired derivatives.

A novel series of 5′-amino-2′,5′-dideoxy-2′,2′-difluorocytidine derivatives, represented by 1, have been prepared via three different synthetic routes in order to profile them as potential anticancer agents.