کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5433444 1508989 2017 15 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Strategies for improving the payload of small molecular drugs in polymeric micelles
ترجمه فارسی عنوان
استراتژی برای بهبود بارگیری داروهای مولکولی کوچک در میسلهای پلیمری
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی

In the past few years, substantial efforts have been made in the design and preparation of polymeric micelles as novel drug delivery vehicles. Typically, polymeric micelles possess a spherical core-shell structure, with a hydrophobic core and a hydrophilic shell. Consequently, poorly water-soluble drugs can be effectively solubilized within the hydrophobic core, which can significantly boost their drug loading in aqueous media. This leads to new opportunities for some bioactive compounds that have previously been abandoned due to their low aqueous solubility. Even so, the payload of small molecular drugs is still not often satisfactory due to low drug loading and premature release, which makes it difficult to meet the requirements of in vivo studies. This problem has been a major focus in recent years. Following an analysis of the published literature in this field, several strategies towards achieving polymeric micelles with high drug loading and stability are presented in this review, in order to ensure adequate drug levels reach target sites.

The strategies for improve the payload of micelles.196

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 261, 10 September 2017, Pages 352-366
نویسندگان
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