کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5434015 1509004 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Controlled nanoparticle release from a hydrogel by DNA-mediated particle disaggregation
ترجمه فارسی عنوان
انتشار نانوذرات کنترل شده از یک هیدروژل به وسیله تقسیم بندی ذرات توسط ماده متمرکز شده است
موضوعات مرتبط
مهندسی و علوم پایه مهندسی مواد بیومتریال
چکیده انگلیسی

For many pharmaceutical applications, it is important that different drugs are present in the human body at distinct time points. Typically, this is achieved by a sequential administration of different therapeutic agents. A much easier alternative would be to develop a drug delivery system containing a whole set of medically active compounds which are liberated in an orchestrated and controlled manner. Yet, such a controlled, sequential release of drugs from a carrier system that can be used in a physiological situation is difficult to achieve. Here, we combine two molecular mechanisms, i.e. a build-up of osmotic pressure by the depletion of a control molecule and triggered disaggregation of nanoparticle clusters by synthetic DNA sequences. With this approach, we gain spatio-temporal control over the release of molecules and nanoparticles from a gel environment. The strategy presented here has strong implications for developing complex drug delivery systems for wound healing applications or for the sustained release of pharmaceuticals from a drug-loaded gel and will lower the need for multiple drug administrations.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Controlled Release - Volume 246, 28 January 2017, Pages 71-78
نویسندگان
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