A novel kind of polysulfone material with excellent biocompatibility modified by the sulfonated hydroxypropyl chitosan

- SHPCS was a kind of heparan with very effective anticoagulant property.
- SHPCS was a good antimicrobial.
- SHPCS was covalently immobilized on PSf materials.
- The hydrophilicity of PSf-SHPCS membrane was improved to a great extent.
- The PSf-SHPCS membrane had fine anticoagulant and antibacterial properties.

In order to ameliorate the biocompatibility of polysulfone (PSf), sulfonated hydroxypropyl chitosan (SHPCS) was grafted from PSf membrane material by Schiff-Base reaction. The original and modified membranes were characterized by attenuated total reflectance-Fourier transform infrared spectroscope (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy (SEM), water contact angle (WCA) measurement, tensile strength test and antibacterial test in vitro, and the results indicated that the PSf modified by SHPCS (PSf-SHPCS) was synthesized successfully, the hydrophilicity of PSf-SHPCS membrane was improved to a great extent, all the membranes possessed good stability in physiological condition and the PSf-SHPCS membrane had good antibacterial property. Protein adsorption, platelet adhesion, hemolysis assay, plasma recalcification time, activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT) and whole blood clotting time were executed to evaluate the hemocompatibility of membranes decorated by SHPCS, and the results demonstrated that the modified membrane had fine hemocompatibility.

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