Solvothermal synthesis of hydroxyapatite with various morphologies using trimethyl phosphate as organic phosphorus source

Hydroxyapatite (HAP) materials with various morphologies including microrods, nanoparticle-assembled microflowers (NAMs), nanoparticle-assembled dendritic superstructures (NADSs), and microrod-assembled ordered arrays (MAOAs) are prepared by a facile solvothermal synthesis strategy using trimethyl phosphate as an organic phosphorus source. The morphologies of the as-prepared HAP products vary significantly with the change of the solvothermal temperature and amount of NaOH. The present study provides a new platform for the synthesis of HAP materials with various morphologies. Among the as-prepared HAP products, the HAP MAOAs show similar structures to those of apatite in the hard tissues of vertebrates. The as-prepared products show excellent biocompatibility, and thus are potentially useful in biomedical fields.