کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5493142 1526261 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Radiobiological concepts for treatment planning of schemes that combines external beam radiotherapy and systemic targeted radiotherapy
ترجمه فارسی عنوان
مفاهیم رادیو بیوژیکی برای برنامه ریزی درمان طرح هایی که رادیوتراپی پرتوهای خارجی و سیستم رادیوتراپی هدفمند را ترکیب می کند
کلمات کلیدی
رادیوتراپی ترکیبی مدل خطی خطی، پرتو درمانی پرتوهای خارجی، پرتودرمانی مولکولی، برنامه ریزی درمان بیولوژیک، مدل های پاسخ دز،
موضوعات مرتبط
مهندسی و علوم پایه فیزیک و نجوم ابزار دقیق
چکیده انگلیسی


- A formulation for calculation of TCP and NTCP for CIERT is proposed;
- The linear-quadratic model is adapted for CIERT schemes.
- Biological planning is applied for evaluations of prescriptions in combined radiotherapy.

The combination of radiotherapy modalities with external bundles and systemic radiotherapy (CIERT) could be a reliable alternative for patients with multiple lesions or those where treatment planning maybe difficult because organ(s)-at-risk (OARs) constraints. Radiobiological models should have the capacity for predicting the biological irradiation response considering the differences in the temporal pattern of dose delivering in both modalities. Two CIERT scenarios were studied: sequential combination in which one modality is executed following the other one and concurrent combination when both modalities are running simultaneously. Expressions are provided for calculation of the dose-response magnitudes Tumor Control Probability (TCP) and Normal Tissue Complication Probability (NTCP). General results on radiobiological modeling using the linear-quadratic (LQ) model are also discussed. Inter-subject variation of radiosensitivity and volume irradiation effect in CIERT are studied. OARs should be under control during the planning in concurrent CIERT treatment as the administered activity is increased. The formulation presented here may be used for biological evaluation of prescriptions and biological treatment planning of CIERT schemes in clinical situation.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Nuclear Instruments and Methods in Physics Research Section A: Accelerators, Spectrometers, Detectors and Associated Equipment - Volume 865, 1 September 2017, Pages 152-156
نویسندگان
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