کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5498171 | 1399970 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Whole-brain Irradiation Field Design: A Comparison of Parotid Dose
ترجمه فارسی عنوان
طرح ریزی پرتوی کل مغز: مقایسۀ دوز پاروتید
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موضوعات مرتبط
مهندسی و علوم پایه
فیزیک و نجوم
تشعشع
چکیده انگلیسی
Whole-brain radiation therapy (WBRT) plays an important role in patients with diffusely metastatic intracranial disease. Whether the extent of the radiation field design to C1 or C2 affects parotid dose and risk for developing xerostomia is unknown. The goal of this study is to examine the parotid dose based off of the inferior extent of WBRT field to either C1 or C2. Patients treated with WBRT with either 30âGy or 37.5âGy from 2011 to 2014 at a single institution were examined. Parotid dose constraints were compared with Radiation Therapy Oncology Group (RTOG) 0615 nasopharyngeal carcinoma for a 33-fraction treatment: mean <26âGy, volume constraint at 20âGy (V20)â<â20âcc, and dose at 50% of the parotid volume (D50)â<â30âGy. Biologically effective dose (BED) conversions with an α/β of 3 for normal parotid were performed to compare with 10-fraction and 15-fraction treatments of WBRT. The constraints are as follows: meanâ<âBED 32.83âGy, V15.76 (for 10-fraction WBRT) or V17.35 (for 15-fraction WBRT)â<â20âcc, and D50â<âBED 39.09âGy. Nineteen patients treated to C1 and 26 patients treated to C2 were analyzed. Comparing WBRT to C1 with WBRT to C2, the mean left, right, and both parotids' doses were lower when treated to C1. Converting mean dose to BED3, the parotid doses were lower than BED3 constraint of 32.83âGy: left (30.12âGy), right (30.69âGy), and both parotids (30.32âGy). V20 to combined parotids was lower in patients treated to C1. When accounting for fractionation of WBRT received, the mean corrected V20 volume was less than 20âcc when treating to C1. D50 for C1 was lower than C2 for the left parotid, right parotid, and both parotids. BED3 conversion for the mean D50 of the left, right, and both parotids was less than 39.09âGy. In conclusion, WBRT to C1 limits parotid dose, and parotid dose constraints are achievable compared with inferior border at C2. A possible mean parotid dose constraint with BED3 should be less than 32.83âGy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Medical Dosimetry - Volume 42, Issue 2, Summer 2017, Pages 145-149
Journal: Medical Dosimetry - Volume 42, Issue 2, Summer 2017, Pages 145-149
نویسندگان
Cheng-Chia M.D., Ph.D., Yen-Ruh B.S., Ashish M.D., Anurag B.A., Cheng-Hung B.A., Matthew E. B.S., Jacquelyn I.S. B.A., Akhil B.S., Heva J. M.P.H., Steven R. M.D., Simon K. M.D., Ph.D., Tony J.C. M.D.,