کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5505034 | 1400259 | 2017 | 6 صفحه PDF | دانلود رایگان |
- CSF IL-1β and bFGF levels were elevated in patients with HHV-6B encephalitis.
- IL-1β increased viral gene expression during the initial phase of HHV-6B infection.
- bFGF maintained viral gene expression after HHV-6B infection.
Human herpesvirus 6B (HHV-6B) causes exanthema subitum in infants and is known to be mildly pathogenic. However, HHV-6B infection can induce febrile seizures in a high percentage of patients, and in rare cases, result in encephalitis. We detected higher levels of interleukin (IL)-1β and basic fibroblast growth factor (bFGF) in the cerebrospinal fluid (CFS) of patients with HHV-6B encephalitis when compared to those in patients with non-HHV-6B-induced febrile seizures. In vitro, IL-1β and bFGF enhanced HHV-6B gene expression in infected U373 astrocytes during the initial and maintenance phases of infection, respectively. These findings indicated that IL-1β and bFGF contribute to HHV-6B growth and the onset of encephalitis.
Journal: Biochemical and Biophysical Research Communications - Volume 486, Issue 3, 6 May 2017, Pages 706-711