کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5506181 | 1400288 | 2017 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Isoamyl alcohol odor promotes longevity and stress tolerance via DAF-16 in Caenorhabditis elegans
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کلمات کلیدی
NGMDDWDAF-16Longevity - دیرزیستی یا طول عمرdouble-distilled water - آب دوتاییAcetic acid - اسید استیکisoamyl alcohol - ایزوآمیل الکلOdor - بو، رایحهHeat tolerance - تحمل گرماnematode growth medium - رشد متوسط نماتدwild-type - نوع وحشیpolymerase chain reaction - واکنش زنجیره ای پلیمرازPCR - واکنش زنجیرهٔ پلیمراز
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
The possibility that odor plays a role in lifespan regulation through effects on the nervous system is indicated by research on Caenorhabditis elegans. In fact, ablation of AWA and AWC, which are suggested as olfactory neurons, has been shown to extend lifespan via DAF-16, a homolog of FoxO. However, the effects of odor stimuli on the lifespan still remain unclear. Thus, we here aimed to clarify the effect of attractive and repulsive odors on longevity and stress tolerance in C. elegans and to analyze the pathways thereof. We used isoamyl alcohol as an attractive odor, and acetic acid as a repellent component, as identified by chemotaxis assay. We found that isoamyl alcohol stimulus promoted longevity in a DAF-16-dependent manner. On the other hand, acetic acid stimulus promoted thermotolerance through mechanisms independent of DAF-16. Above all, our results indicate that odor stimuli affect the lifespan and stress tolerance of C. elegans, with attractive and repulsive odors exerting their effects through different mechanisms, and that longevity is induced by both activation and inactivation of olfactory neurons.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 485, Issue 2, 1 April 2017, Pages 395-399
Journal: Biochemical and Biophysical Research Communications - Volume 485, Issue 2, 1 April 2017, Pages 395-399
نویسندگان
Chiho Kurino, Tsubasa Furuhashi, Kaori Sudoh, Kazuichi Sakamoto,