کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5506982 1536896 2017 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Selenium nanoparticles induce suppressed function of tumor associated macrophages and inhibit Dalton's lymphoma proliferation
ترجمه فارسی عنوان
نانوذرات سلنیوم باعث کاهش عملکرد ماکروفاژهای مرتبط با تومور و جلوگیری از تکثیر لنفوم دالتون
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی


- It was found that the decreased profiling of TAMs such as adherence, fusion, receptor CD54 or ICAM-1, fusion CD47, CD172a and phagocytosis enhanced as compare to control.
- The ROS generation enhanced many fold as compare to control.
- It was also found that the cell proliferation was decreased upon the treatment of tams with SeNPs.

Selenium Nanoparticle (SeNPs) is reported that it enhances and maintains optimal immune during infection and malignancies. To this end, we examined the role of selenium on TAMS whose anti-tumor function suppressed which favor tumor progression. BALB/c (H2d) strain of mice non-Hodgkin type of Dalton's cell line was used to check the role of carboxlic group induced, synthesized SeNPs on TAMs. Screening of IC50 value was done primarily trypen blue exclusion assay and 50% proliferation of DL cells inhibited 40 ng/ml to 50 ng/. Treatment also decreases ΔΨm, fragmentation of DNA of DL cells and arrest cells cycle in G1/G0 phage. Untreated TAMs cells showing suppressed expression of ROS, adhesion, phagocytosis, fusion and receptor profiling such as ICAM-1, CD47, CD172α. Which was induced more as compare to untreated group. SeNPs have potential to induce the anti-tumor function of TAMs whose anti-tumor function down-regulated pliable shifted towards tumor progression. It decreased the proliferation of DL cell by inducing apoptosis. Therefore, the synthesized SeNPs could be used for imaging diagnosis and cancer therapy which must be cost effective with negligible side effects shifted towards tumor progression. It decreased the proliferation of DL cell by inducing apoptosis.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemistry and Biophysics Reports - Volume 12, December 2017, Pages 172-184
نویسندگان
, , , , , , ,