کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5511267 | 1539852 | 2017 | 26 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Role of epigenetic modulation in cancer stem cell fate
ترجمه فارسی عنوان
نقش مدولاسیون اپی ژنتیک در سرنوشت سلول های بنیادی سرطان
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شیمی
چکیده انگلیسی
A sub-population of the tumor micro-environment consists of cancer stem cells (CSCs), which are responsible for the initiation and recurrence of cancer. Recently, epigenetic processes such as DNA methylation, histone modification, and chromatin remodeling have been found to be involved in inducing epigenetic factors in CSCs. Most of these processes, such as DNA methylation, generally occur in the genome that is rich in Cytosine-Guanine repeat sequences, also known as CpG islands, which are distributed throughout the human genome. The Polycomb gene (PcG) complex is a chromatin modifier facilitating the maintenance of embryonic and adult stem cells. Recent evidence suggests that the PcG is also involved in maintaining CSC stemness. We have presented various aspects and examples of how epigenetic modulation may drive or promote tumorigenesis and metastasis by alteration of key transcriptomic programs and signaling pathways in CSCs.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: The International Journal of Biochemistry & Cell Biology - Volume 90, September 2017, Pages 9-16
Journal: The International Journal of Biochemistry & Cell Biology - Volume 90, September 2017, Pages 9-16
نویسندگان
Abhijeet Deshmukh, Mudra Binju, Frank Arfuso, Philip Newsholme, Arun Dharmarajan,