کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5514197 | 1541591 | 2017 | 5 صفحه PDF | دانلود رایگان |
- The effects of the nitric oxide donor SNP on anxiety were studied.
- Acute exposure to SNP induced anxiolysis in rats.
- These effects seem to be time and dose dependent.
- Repeated exposure to SNP did not alter anxiety in rats.
The nitric oxide (NO) donor sodium nitroprusside (SNP) actually is under investigation for the treatment of schizophrenia. That anxiety disorders are noted to occur commonly in schizophrenia patients is known. Contradictory results were reported however, concerning the effects of SNP in animal models of anxiety disorders. The present study investigated the effects of acute and repeated administration of SNP on anxiety-like behaviour in rats assessed in the light/dark test. The effects of SNP on motility in a locomotor activity chamber were also investigated in rats. Acute administration of 1Â mg/kg SNP 30 but not 60Â min before testing induced anxiolytic-like behaviour which cannot be attributed to changes in locomotor activity. Conversely, a single injection of 3Â mg/kg SNP at 30Â min before testing depressed rats' general activity, while at 60Â min this dose did not influence performance of animals either in the light/dark or in the motor activity test. Repeated application of SNP (1 and 3Â mg/kg, for 5 consecutive days) did not alter rodents' performance in the above described behavioural paradigms. The present results suggest that the effects exerted by SNP in the light/dark test in rats are dose, time and treatment schedule-dependent. The current findings propose also a narrow therapeutic window for SNP in this animal model of anxiety.
Journal: Nitric Oxide - Volume 69, 30 September 2017, Pages 56-60