کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5515002 1400742 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Original articleAttenuation of stress induced memory deficits by nonsteroidal anti-inflammatory drugs (NSAIDs) in rats: Role of antioxidant enzymes
ترجمه فارسی عنوان
مقاله کوتاه کاهش ضایعات حافظه ناشی از استرس توسط داروهای ضد التهابی غیراستروئیدی در موش صحرایی: نقش آنزیم های آنتیاکسیدان
کلمات کلیدی
استیل کولین استراز، آنزیم آنتیاکسیدان، پراکسیداسیون لیپید، حافظه، پروستاگلاندین ها،
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

BackgroundRepeated stress paradigms have been shown to cause devastating alterations on memory functions. Stress is linked with inflammation. Psychological and certain physical stressors could lead to neuroinflammation. Inflammatory process may occur by release of mediators and stimulate the production of prostaglandins through cyclooxygenase (COX). Treatment with COX inhibitors, which restrain prostaglandin production, has enhanced memory in a number of neuroinflammatory states showing a potential function for raised prostaglandins in these memory shortfalls. In the present study, potential therapeutic effects of indomethacin and diclofenac sodium on memory in both unrestraint and restraint rats were observed.Methods and resultsTwo components, long term memory and short term memory were examined by Morris water maze (MWM) and elevated plus maze (EPM) respectively. The present study also demonstrated the effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on lipid peroxidation (LPO) and activities of antioxidant enzymes along with the activity of acetylcholinesterase (AChE). Results of MWM and EPM showed significant effects of drugs in both unrestraint and restraint rats as escape latency and transfer latency, in respective behavioral models were decreased as compared to that of control. This study also showed NSAIDs administration decreased LPO and increased antioxidant enzymes activity and decreased AChE activity in rats exposed to repeated stress.ConclusionIn conclusion this study suggests a therapeutic potential of indomethacin and diclofenac against repeated stress-induced memory deficits.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 69, Issue 2, April 2017, Pages 300-305
نویسندگان
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