کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5515069 1400746 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationAntidepressant activity of zinc: Further evidence for the involvement of the serotonergic system
ترجمه فارسی عنوان
ارتباط کوتاه فعالیت ضد انعقاد روی: شواهد بیشتر برای دخالت سیستم سروتونرژیک
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

BackgroundThe present study sought to further evaluate the role of the serotonergic system especially the postsynaptic 5-HT1A receptors (5-HT1AR) in the mechanism of antidepressant action of zinc.MethodsMessenger RNA (mRNA), protein level, and 5-HT1AR density as well as the rate of monoamine (dopamine, DA, and serotonin) metabolism in the prefrontal cortex (PFC) and hippocampus (Hp) of rats subjected to acute and chronic (21 days) zinc (5 mg Zn/kg) treatment were measured.ResultsAcute or chronic zinc treatment did not induce any changes in 5-HT1AR mRNA levels in the PFC or Hp of rats. However, chronic zinc treatment induced increases in both 5-HT1AR protein levels and density of 5-HT1A receptor binding sites in the Hp of rats. Chronic zinc treatment also increased tissue levels of serotonin metabolite and turnover in the rat Hp. On the other hand, DA, DOPAC, HVA tissue levels increased while DOPAC/DA and 3MT/DA decreased in the PFC of rats after chronic zinc treatment. Acute treatment induced increases only in tissue levels of DOPAC, and DOPAC/DA.ConclusionsOur results confirm that the antidepressant effects of zinc are mediated in concert with the modulation of the serotonergic system including postsynaptic 5-HT1ARs and allude to a possible involvement of dopaminergic neurotransmission in this action.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 69, Issue 3, June 2017, Pages 456-461
نویسندگان
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