کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5515124 1400749 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Short communicationApoptotic effect of chalcone derivatives of 2-acetylthiophene in human breast cancer cells
ترجمه فارسی عنوان
ارتباطات کوتاه مدت اثر آپوپتوزی مشتقات کلوکون 2-استیل تیوفن در سلول های سرطان پستان انسان
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
چکیده انگلیسی

BackgroundA variety of chalcones have demonstrated cytotoxic activity toward several cancer cell lines. This study aimed to investigate the cytotoxicity of four chalcones derivatives of 2-acetylthiophene in human breast cancer cell lines.MethodsMCF-7 and MDA-MB-231 cells were treated with synthesized chalcones and the cytotoxicity was evaluated by tetrazolium dye (MTT), live/dead, and DAPI assays.ResultsChalcones significantly decreased MCF-7 and MDA-MB-231 cells viability in vitro in a dose dependent manner. After 48 h treatment, the IC50 values ranging from 5.52 to 34.23 μM. Chalcone 3c displayed the highest cytotoxic activity from all the tested compounds. Cytotoxic effects of compounds were confirmed in the live/dead assay. In addition, DAPI staining revealed that these compounds induce death by apoptosis.ConclusionThe data speculate that chalcone derivatives of 2-acetylthiophene may represent a source of therapeutic agents for human breast cancer.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Pharmacological Reports - Volume 69, Issue 1, February 2017, Pages 156-161
نویسندگان
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