کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5516692 | 1542691 | 2017 | 7 صفحه PDF | دانلود رایگان |
- Supramolecular characteristics studied by the UV-VIS-NIR and DOSY-NMR spectra.
- Fibrous self-assembly observed by the AFM, SEM and TEM micrographs.
- Bathochromic shifts in the UV-VIS-NIR spectra indicates fibrous J-type aggregates.
- DOSY-NMR showed non-linear dependence and results in a self-assembly behavior.
Supramolecular characteristics of two spermine amides of betulinic acid (1 and 2) were studied by measuring and evaluating their UV-VIS-NIR spectra in aqueous acetonitrile and DOSY-NMR spectra in tetradeuteromethanol, accompanied by atomic force microscopy (AFM) images, scanning electron microscopy (SEM) micrographs, and transmission electron microscopy (TEM) micrographs. Fibrous supramolecular self-assembly of 1 and 2 was observed by AFM images, as well as by the SEM and TEM micrographs. Bathochromic shifts of the absorbance maximum at 870Â nm to 1015-970Â nm in the UV-VIS-NIR spectra were observed with increasing water content in the acetonitrile/water systems, indicating formation of fibrous J-type aggregates. Variable temperature DOSY-NMR spectral measurement showed non-linear dependence that also suggests self-assembly behavior of the studied systems. Chiral supramolecular structures were formed by self-assembling due to the chirality of the monomeric molecules. Application of aqueous media during self-assembly procedures is an important factor in the development of targeted drug delivery systems.
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Journal: Steroids - Volume 117, January 2017, Pages 90-96