کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5518314 1543951 2017 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The rs10993994 functional polymorphism in the MSMB gene promoter increase the risk of prostate cancer in an Iranian population
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
The rs10993994 functional polymorphism in the MSMB gene promoter increase the risk of prostate cancer in an Iranian population
چکیده انگلیسی

Microseminoprotein-beta (MSMB) is one of the most abundant proteins in human seminal plasma. The current study was aimed to assess the impact of MSMB rs10993994, rs12770171, rs10994385 variants on prostate cancer (PCa) risk in a sample of Iranian population. This case-control study was executed on 169 pathologically confirmed PCa patients and 182 benign prostatic hyperplasia (BPH). Genotyping was performed by using the PCR-RFLP method. Our findings showed that rs10993994 variant significantly increased the risk of PCa in codominant (OR = 1.64, 95%CI = 1.04-2.59, P = 0.038, CT vs TT) and overdominant (OR = 1.64, 95%CI = 1.03-2.43, P = 0.039, TC vs TT + CC) models. However, no significant association was observed among rs10994385 G > C and rs12770171 C > T polymorphisms and PCa risk.In summary, the findings showed that MSMB rs10993994 polymorphism increased the risk of PCa in an Iranian population. To verify our findings, well-designed studies with larger sample sizes and representing various ethnicities are needed.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Meta Gene - Volume 14, December 2017, Pages 100-104
نویسندگان
, , , , , , ,