کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5518339 1543952 2017 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interleukin-1β (rs1143634) polymorphism and adiposity traits in Quilombolas
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Interleukin-1β (rs1143634) polymorphism and adiposity traits in Quilombolas
چکیده انگلیسی


- The distribution of rs1143634polymorphism were TT genotype was (11.1%), CT (23.5%) and CC (59.0%) in Quilombola communities.
- Interactions between soda consumption and genotype were associated to high conicity index
- After socioeconomic and lifestyle adjustment T variant of rs1143634 is a protection factor for central obesity in Quilombola communities

BackgroundRecent studies have shown a relationship between adiposity traits and a low-grade inflammation of adipose tissue resulting from chronic activation of the innate immune system as interleukin-1 beta (IL-1β). However, this association remains controversial. Besides, the Quilombola communities that have presumed different genetic background and it could change the obesity vulnerability.ObjectiveTo estimate the association between IL-1β and adiposity traits like obesity or abdominal obesity in Quilombola communities. A cross-sectional population-based study was conducted the northern region of Minas Gerais with the representative sample of 756 individuals aged ≥ 18 years. The swab oral was used for DNA extraction and the IL-1β rs1143634 polymorphism was evaluated by RFLP-PCR. The interviewed and measures were done using specific protocols. It was estimated to outcomes: the overweight (body mass index ≥ 25 kg/m2), abdominal obesity (waist circumference ≥ 88 cm for women and ≥ 102 cm for men), and the high conicity index (≥ 1.18 cm or women e ≥ 1.25 cm for men). Poisson regression multivariate models were constructed considering genotype and the outcomes, adjusted for socioeconomic and lifestyle variables.ResultsThe distribution of IL-1β for the TT genotype was (11.9%), CT (25.1%) and CC (63.0%). The women TT carriers showed a higher regular soft drink consumption (p = 0.048). The height was lower in man TT carriers (p = 0.041) and lower weight (p = 0.025). The CT genotype showed higher BMI (p = 0.037). The CT and TT carriers showed less prevalence ratio to abdominal obesity even adjusted to socioeconomic and lifestyle variables, there no associations between genotype and overweight or high conicity index.ConclusionsIn conclusion, after socioeconomic and lifestyle adjustment T variant of rs1143634 is a protection factor for central obesity in Quilombola communities.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Meta Gene - Volume 13, September 2017, Pages 78-84
نویسندگان
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