The association of GSTM1 and GSTT1 deletion polymorphisms with lung cancer risk: Evidence from an updated meta-analysis

Lung cancer is considered as most frequent malignancy all over the world. Glutathione S transferases are the active candidates for the susceptibility of lung cancer. Different studies have reported the association of GSTM1 and GSTT1 null deletion polymorphism with risk of lung cancer. But inconsistent results were reported. Therefore aim of the current study was to elucidate the role of GSTM1 and GSTT1 polymorphism in lung cancer development. PubMed, NCBI, EMBASE and Web of Science were comprehensively searched to explore the relationship of GSTM1 and GSTT1 with lung carcinoma in various populations in the era of last ten years. ORs with 95% CI were used to find the association between risk of lung carcinoma and GSTM1 and GSTT1 polymorphism. MedClac and STATA were used to analyze and interpret the results. The study comprise of 6491 lung carcinoma cases and 7807 normal healthy controls. The data showed that GSTM1 was strongly associated (OR = 1.31) with risk of lung cancer whereas no association was observed for GSTT1 (OR = 0.27) null deletion. The current study evinced that GSTM1 may contribute towards the development of lung cancer. Furthermore, properly designed studies with greater sample size are required to confirm validity the results.

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