کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5518388 1401066 2017 3 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله
Differential genetic background of primary and secondary tuberculosis in Russians
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Differential genetic background of primary and secondary tuberculosis in Russians
چکیده انگلیسی

Tuberculosis is a global healthcare challenge. Host genetic factors were proven to modify risk of the disease. Genome-wide association studies revealed a number of loci associated with TB in different populations. However, no systematic analysis of genetic bases of susceptibility to different clinical stages, such as primary TB and reactivation, was carried out. We set out to validate the results of GWASs in Russians of West Siberia with a consideration of primary and secondary TB. We chose 45 SNP from five large GWASs and genotyped 445 healthy individuals and 323 TB patients including 74 with primary TB and 249 with reactivation. We found that the rs7821565 and rs40363 SNPs were associated with primary TB in Russians (p = 0.019 and 1.4e − 3, respectively), while rs10515787 and rs2837857 were associated with secondary TB (p = 1.2e − 3 and 0.039, respectively). The results suggest genetic basis of primary and secondary TB differs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Meta Gene - Volume 11, February 2017, Pages 178-180
نویسندگان
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