Associations of PPAR-γ, APM1 and APOC1 gene polymorphisms with metabolic syndrome in children: A case-control study

ObjectivesWe aimed to evaluate the association of genes of peroxisome proliferator-activated receptor-γ (PPARγ), adiponectin (APM1) and apolipoprotein E (APOC1) polymorphisms with metabolic syndrome (MS) in children.MethodsA matched case-control study was conducted with 114 MS cases and 114 controls. Anthropometric measurements and a questionnaire survey were conducted in all subjects. The polymerase chain reaction method and DNA sequencing were used for genotyping of single nucleotide polymorphism for PPARγ (rs1801282), APM1 (rs266729) and APOC1 (rs4420638).ResultsAfter adjustments for sex, age, educational level of parents, physical activity, dietary patterns, pubertal development and household income, there were significant associations between rs266729 (OR = 1.91, 95% CI: 1.01-3.62), rs4420638 (OR = 2.21, 95%CI: 1.19-4.10) polymorphisms and the risk of MS in children. However, no association was found between rs1801282 polymorphism and MS.ConclusionThe results showed that the genetic variants of the APM1 and the APOC1 were associated with MS in children.