کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5518533 | 1543974 | 2017 | 6 صفحه PDF | دانلود رایگان |
- Altered genetic and metabolic targets by obesity in adipose stem cells population
- Gas5 involved in glucocorticoid resistance such as altered target
- Additional metabolic and inflammation conditions on obese adipose stem cells
Adipose tissue is a significant source of mesenchymal stem cells for regenerative therapies; however, caution should be taken as their environmental niche can affect their functional properties. We have previously demonstrated the negative impact of obesity on the function of adipose-derived stem cells (ASCs). Here we have evaluated other possible properties and targets that are altered by obesity such as the recently described long non-coding molecule Gas5, which is involved in glucocorticoid resistance. Using ASCs isolated from obese (oASCs) and control subjects (cASCs), we have analyzed additional metabolic and inflammatory conditions that could be related with their impaired therapeutic potential and consequently their possible usefulness in the clinic.
Journal: Molecular Genetics and Metabolism Reports - Volume 12, September 2017, Pages 51-56