کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5518533 1543974 2017 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Adipose stem cells from obese patients show specific differences in the metabolic regulators vitamin D and Gas5
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوشیمی، ژنتیک و زیست شناسی مولکولی (عمومی)
پیش نمایش صفحه اول مقاله
Adipose stem cells from obese patients show specific differences in the metabolic regulators vitamin D and Gas5
چکیده انگلیسی


- Altered genetic and metabolic targets by obesity in adipose stem cells population
- Gas5 involved in glucocorticoid resistance such as altered target
- Additional metabolic and inflammation conditions on obese adipose stem cells

Adipose tissue is a significant source of mesenchymal stem cells for regenerative therapies; however, caution should be taken as their environmental niche can affect their functional properties. We have previously demonstrated the negative impact of obesity on the function of adipose-derived stem cells (ASCs). Here we have evaluated other possible properties and targets that are altered by obesity such as the recently described long non-coding molecule Gas5, which is involved in glucocorticoid resistance. Using ASCs isolated from obese (oASCs) and control subjects (cASCs), we have analyzed additional metabolic and inflammatory conditions that could be related with their impaired therapeutic potential and consequently their possible usefulness in the clinic.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Genetics and Metabolism Reports - Volume 12, September 2017, Pages 51-56
نویسندگان
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