کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5519641 1544408 2017 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Melanopsin-expressing retinal ganglion cells are resistant to cell injury, but not always
ترجمه فارسی عنوان
سلول های گانگلیونی شبکیه بیان کننده ملانپسین مقاوم در برابر صدمات سلولی هستند، اما نه همیشه
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
چکیده انگلیسی

Melanopsin retinal ganglion cells (mRGCs) are intrinsically photosensitive RGCs deputed to non-image forming functions of the eye such as synchronization of circadian rhythms to light-dark cycle. These cells are characterized by unique electrophysiological, anatomical and biochemical properties and are usually more resistant than conventional RGCs to different insults, such as axotomy and different paradigms of stress. We also demonstrated that these cells are relatively spared compared to conventional RGCs in mitochondrial optic neuropathies (Leber's hereditary optic neuropathy and Dominant Optic Atrophy). However, these cells are affected in other neurodegenerative conditions, such as glaucoma and Alzheimer's disease. We here review the current evidences that may underlie this dichotomy. We also present our unpublished data on cell experiments demonstrating that melanopsin itself does not explain the robustness of these cells and some preliminary data on immunohistochemical assessment of mitochondria in mRGCs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 36, September 2017, Pages 77-84
نویسندگان
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