کد مقاله کد نشریه سال انتشار مقاله انگلیسی ترجمه فارسی نسخه تمام متن
5519686 1544410 2017 4 صفحه PDF سفارش دهید دانلود کنید
عنوان انگلیسی مقاله ISI
Integration of mtDNA pseudogenes into the nuclear genome coincides with speciation of the human genus. A hypothesis
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیوفیزیک
پیش نمایش صفحه اول مقاله
Integration of mtDNA pseudogenes into the nuclear genome coincides with speciation of the human genus. A hypothesis
چکیده انگلیسی

Fragments of mitochondrial DNA are known to get inserted into nuclear DNA to form NUMTs, i.e. nuclear pseudogenes of the mtDNA. The insertion of a NUMT is a rare event. Hundreds of pseudogenes have been cataloged in the human genome. NUMTs are, in essence, a special type of mutation with their own internal timer, which is synchronized with an established molecular clock, the mtDNA. Thus insertion of NUMTs can be timed with respect to evolution milestones such as the emergence of new species. We asked whether NUMTs were inserted uniformly over time or preferentially during certain periods of evolution, as implied by the “punctuated evolution” model. To our surprise, the NUMT insertion times do appear nonrandom with at least one cluster positioned at around 2.8 million years ago (Ma). Interestingly, 2.8 Ma closely corresponds to the time of emergence of the genus Homo, and to a well-documented period of major climate change ca. 2.9–2.5 Ma. It is tempting to hypothesize that the insertion of NUMTs is related to the speciation process. NUMTs could be either “riders”, i.e., their insertion could be facilitated by the overall higher genome rearrangement activity during speciation, or “drivers”, i.e. they may more readily get fixed in the population due to positive selection associated with speciation. If correct, the hypothesis would support the idea that evolution of our genus may have happened in a rapid, punctuated manner.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Mitochondrion - Volume 34, May 2017, Pages 20–23