An extensive review on L-methioninase and its potential applications

L-methioninase (METs) catalyses the disintegration of methionine, an essential amino acid into ammonia, α-Keto glutarate and methanethiol. This enzyme has been extensively studied from a wide range of organisms, including plants, terrestrial and marine microbes. Clear and detailed information about the three dimensional structure and potential catalytic activity of L-methioninase from Pseudomonas and Citrobacter sp. have been well documented. This review catalogues the prominent sources of L-methioninase, methods of its production and purification, characterization and as well as its biological roles. In the same breath, this article reveals both the past and present applications of this important enzyme and discusses its upcoming scenarios.